ROLE OF PARTURITION ON BRAIN DEVELOPMENT

        Cell death peaks around the time of birth in several brain regions of the mouse. In addition, preliminary data show that natural (vaginal) birth might be important for the normal course of cell death because Cesarean born mice have increased cell death in several brain regions compared to vaginally born mice. Birth entails a dramatic entry to the world and, in preparation, key peripheral organs (e.g., lungs, gut, and heart) undergo physiological changes. We hypothesize that birth is also an important event in brain development. In this project, we are studying how birth influences cell death in the brain by manipulating the timing or mode of birth in mice. We are also interested in identifying mechanisms underlying cell death at birth, as well as exploring additional effects of birth on brain development and behavior.

BIRTH TEAM 

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Dr. Castillo-Ruiz

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Yarely Hoffiz

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Jennifer Gray

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Taylor Hite

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Megan Hall

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Emma Ramlall

Does birth trigger cell death in the developing brain?

February 2020

Castillo-Ruiz A, Hite TA, Yakout DW, Rosen TJ, Forger NG. eNeuro.  doi: 10.1523/ENEURO.0517-19.2020

Microglial depletion causes region-specific changes to developmental neuronal cell death in the mouse brain

August 2019

Jacobs AJ, Castillo-Ruiz A, Cisternas CD, Forger NG . Dev Neurobiol.  doi: doi: 10.1002/dneu.22706

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Ariana Joseph McNeil

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Tobi Mayomi

Effects of sex and androgen manipulations on Onuf's nucleus of rhesus macaques 

April 2018

Forger NG, Ruszkowski E, Jacobs A, Wallen K. Hormones and Behavior.  doi: 10.1016/j.yhbeh.2018.03.003.

PUBLISHED WORK

Birth delivery mode alters perinatal cell death in the mouse brain

November 2018

Castillo-Ruiz A, Mosley M, Jacobs AJ, Hoffiz YC, Forger NG. PNAS.  doi:10.1073/pnas.1811962115

Minocycline causes widespread cell death and increases microglial labeling in the neonatal mouse brain

June 2017

Strahan JA, Walker WH, Montgomery TR, Forger NG. Dev Neurobioldoi: 10.1002/dneu.22457.

Patterns of cell death in the perinatal mouse forebrain

January 2017

Mosley M, Shah C, Morse KA, et al. J Comp Neurol. doi: 10.1002/cne.24041.

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